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Is it safe to prescribe opioid analgesics to methadone patients?

What information does a patient's methadone clinic need about his/her outpatient medical treatment?

Is it appropriate to prescribe benzodiazepines to methadone patients?

Do any special arrangements need to be made for the inpatient care of a methadone patient?

 

 

Is it safe to prescribe opioid analgesics to methadone patients?

Yes.  Patients on a stable dose of methadone develop nearly complete tolerance to the analgesic, sedative, and euphorigenic effects of methadone. They receive no pain relief from their regular, daily methadone dose.  Adequate pain control requires maintaining a patient's establishing tolerance threshold with methadone at the usual dose, then providing additional analgesia.  

Non-narcotic analgesics should be used when pain is not severe. In the event of more severe pain, it is appropriate to use opioid agonist medication.  The dose of an opioid-agonist may need to be increased because of cross-tolerance to methadone. Also, the duration of analgesia may be less than usual. 

It is very important to avoid using mixed agonist-antagonist medications such as pentazocine (Talwin), butorphanol tartrate (Stadol) and nalbuphine hydrocholride (Nubain). Severe opiate abstinence syndrome can be precipitated by this type of medication.
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What information does a patient's methadone clinic need about his/her outpatient medical treatment?

The clinic will need verification of the patient's diagnosis, prescribed medication, and any medication administered directly to the patient.
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Is it appropriate to prescribe benzodiazepines to methadone patients?

Generally, no. In accordance with the American Psychiatric Association's practice guideline for the treatment of panic disorder,  we strongly discourage the use of benzodiazepines by our patients.  Iatrogenic complications from use of this class of medication are very common among methadone patients.  We commonly see marked functional deterioration (frequent intoxication, impaired judgement, disorientation, etc) in patients being treated with benzodiazepines, even when the medication was prescribed for legitimate reasons.

There are, however, some methadone patients who do benefit from benzodiazepine therapy. For this reason, we do not arbitrarily ban the use of prescribed benzodiazepines.  But we do ask that their use be coordinated with the clinic's medical staff.  The patient's medical provider would need the following information in order to determine whether the benefits of benzodiazepine therapy outweigh the risks in light of the patient's participation in opioid therapy:

Name of benzodiazepine and instructions.

Diagnois for which the medication is prescribed.

Non-benzodiazepine treatments that have been tried and failed and how that determination was made.

Length of time you expect the patient to need this medication.

Questions about these procedures should be directed to the patient's ETS medical provider.
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Do any special arrangements need to be made for the inpatient care of a methadone patient?

When a methadone patient enters the hospital, medical staff need to contact the clinic to verify the patient's current methadone dose. 

Upon discharge, the patient should be provided with documentation showing:

Dates of hospitalization

Diagnoses

Any and all medication administered to the patient, including ER medication and anesthesia.  Methadone dosing information is especially important. A copy of pharmacy or hospital ward medication logs may be used for this purpose.

All discharge medication, especially methadone.  

Name, title, and phone number of person providing the information.

The above information is required under current FDA regulations. It should be provided even if the patient's discharge is AMA. 
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Review Article
Jim Anderson, PA-C, an ETS medical provider, has published an article titled Methadone: History, Pharmacology, Outcomes, Clinical Issues, and Future Trends in Advance for Physician Assistants, April 2002, 43 - 48.  For a copy in Adobe Acrobat format, click on the link above.

 

American Family Physician Article on Methadone Therapy
Methadone Therapy for Opioid Dependence, published in the June 15, 2001 edition of American Family Physician, provides an excellent introduction to the medical management of opioid addiction.  To read the article, click on the link above.


 

 

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Evergreen Treatment Services
1700 Airport Way, South
Seattle, WA 98134
(206) 223-3644
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